青岛大学附属医院口腔内科副主任医师，硕士研究生导师

学术任职：

1. 中华口腔医学会牙体牙髓专业委员会青年委员

2. 中华口腔医学会儿童牙病专业委员会委员

3. 青岛市牙体牙髓专业委员会青年委员

科研方面：近5年主持国家自然科学基金青年项目1项,参与国家自然科学基金青年项目一项，参与山东省自己科学基金青年项目1项，发表SCI论文10余篇，以通讯作者或第一作者发表SCI论文 5篇，参编著作一部。主要研究方向为牙髓病与根尖周病的免疫调控机制及骨代谢。

临床方面：长期从事牙体牙髓及根尖周病的治疗，对牙体缺损的修复及显微镜下根管治疗有着丰富的临床经验。

代表性科研成果

1. SCOS3蛋白调控JAK2/STAT3信号在根尖周炎症性骨破坏中的作用；201601-201812；国家自然科学基金委员会；20万元；1/7  81500834

2. MMP-9调控MMP-2在小鼠根尖周炎骨质破坏中的研究；201801-202012；国家自然科学基金委员会；20万元；4/9    81700952

3. MMP-9调控MMP-2在小鼠牙周炎骨质破坏中的作用研究；201708-201912；山东省自然科学基金委员会；8万元； 3/8  ZR2017BH075

4. Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand/ osteoprotegerin. J Endod. Liu L, Zhang C, Hu Y, Peng B. 2012 Jul;38(7) :943-7.  (第一作者)

5. The expression of macrophage migration inhibitory factor is correlated with receptor activator of nuclear factor kappa B ligand in induced rat periapical lesions. J Endod. Liu L, Peng B. 2013 Aug;39(8):984-9.  (第一作者)

6. The expression of MCP-1 and CCR2 in induced rats periapical lesions. Arch Oral Biol. Liu L, Wang L, Wu Y，Peng B. 2014 Feb 22;59(5):492-499.  (第一作者)

7. High-mobility Group Box 1 Is Associated with the Inflammatory Infiltration and Alveolar Bone Destruction in Rats Experimental Periapical Lesions. J Endod. Liu L, Deng J, Ji Q, Peng B. 2017 Jun;43（6）：964-969.  (第一作者)

8. Expression of CX3CL1 and its receptor, CX3CR1, in the development of periapical lesions. Int Endod J. Wang L, Sun Z, Liu L, Peng B. 2014 Mar;47(3):271-9.  (第三作者)

9. Interleukin-17A increases cell migration and MMP-1 expression in human periodontal ligament fibroblasts via p38 MAPK/NF-κB -dependent pathway. J Cell Physiol. Wu Y, Zhu L, Liu L, Zhang J, Peng B. 2014 Mar;229(3):292-9. (第三作者)

10. Characterization and cytocompatibility of thermosensitive hydrogel embedded with chitosan nanoparticles for delivery of bone morphogenetic protein-2 plasmid DNA. Journal of Materials Science-Materials in Medicine.  Li, Dan-Dan; Pan, Jian-Feng; Ji, Qiu-Xia; Yu, Xin-Bo; Liu, Ling-Shuang; Li, Hui; Jiao, Xiao-Ju; Wang, Lei, 2016 Aug;27(8):134. (第五作者)

11. The influence of protaper and waveone on apically extruded debris:a systematic review and meta-analysis. Zhang C, Liu J, Liu L.  J Conserv Dent. 2018 Sep-Oct;21(5):474-480. (通讯作者)

12. JAK2/STAT3 is associated with the inflammatory process in periapical granuloma. Chen Zhang, Jun Liu, Changqing Yuan, Qiuxia Ji, Daiyun Chen, Han Zhao, Weijie Jang, Kangjie Ma, Lingshuang Liu. Int J Clin Exp Pathol. 2019;12(1):190-197. (通讯作者)

13. Refinement and Evaluation of Modified Minimally Invasive Harvest Technique for Subepithelial Connective Tissue. Wang L, Liu L, Song W, Hu F, Zhou J, Ji Q. J Craniofac Surg.  2018 Jul;29(5):1287-1290. (第二作者)

14. Janus蛋白酪氨酸激酶2/信号转导和转录激活因子3信号转导通路在人慢性  根尖周炎中的表达。张晨，刘珺，赵涵，刘玲霜。 口腔医学研究，2019，Vol. 35，Issue (1)：84-88 。 (通讯作者)

15. MMP9 Protects Against LPS-induce Inflammation in Osteoblasts. Hongzhe Zhang, Lingshuang Liu, Chunmiao Jiang, Keqing Pan, Jing Deng, Chunyan Wan Innate Immun. 2020 May;26(4):259-269. doi: 10.1177/1753425919887236. (第二作者)

16. 参编著作一部, 人民卫生出版社《口腔黏膜损害诊断图鉴》,版次2020年1月第一版,标准书号:ISBN 978-7-117-29279-5

17. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases during apical periodontitis development. ChunYan Wan , Lei Li, LingShuang Liu , ChunMiao Jiang , HongZhe Zhang , JianXun Wang. J Endod.2021 Apr 22;S0099-2399(21)00245-4. doi: 10.1016/j.joen.2021.04.005 (第三作者)

18. Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts. Kai Yang , Shuo Xu, Hongmei Zhao , Lingshuang Liu , Xiaofang Lv , Fang Hu , Lei Wang , Qiuxia Ji Int Immunopharmacol. 2021 Feb 12;94:107456. doi:10.1016/j.intimp.2021.107456. (第四作者)

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