副主任医师、硕士研究生导师
职务：
青岛大学附属医院口腔临床医学重点实验室副主任
学术任职：
1.中国抗癌协会肿瘤整形外科专委会 委员
2.山东省保健科技协会口腔颌面头颈医学分会副主任委员
3.山东省疼痛医学会第一届头颈肿瘤青年专委会常务委员
4.青岛市口腔医学会口腔颌面外科专委会 青年委员
5.精准医学杂志 青年编委
6.Frontiers in OncologyAssociate Editor
7.Frontiers in Cell and Developmental BiologyReview Editor
8.国家自然科学基金 评审专家
工作经历：
2014.10-2016.06 西安交通大学口腔医院 医师、主治医师
2016.7-至今 青岛大学附属医院口腔颌面外科 副主任医师
2016.12-2020.11 青岛大学临床医学流动站 博士后
2019.07-2020.07 美国宾夕法尼亚大学牙学院访问学者（公派）
主要从事口腔颌面肿瘤、创伤的诊疗，各类复杂牙的拔除及牙列缺损的种植修复治疗。
主持国家自然科学基金2项及中国博士后基金、省市级科研项目4项，目前在研课题及人才项目配套经费100余万元；以第一及通讯作者发表SCI论文20余篇。
获泰山学者青年专家、齐鲁卫生与健康杰出青年人才、青岛西海岸新区第三批紧缺人才、青岛大学青年卓越人才，青岛大学附属医院高层次人才；获青岛市科技进步奖、山东省高等学校科学技术奖及山东医学科技奖4项。
招收学位类型：学术学位、专业学位研究生
主要研究方向：头颈肿瘤的发病机制、牙颌面骨缺损修复重建的机制研究
代表性文章：
1. Gao L, Zhang Q, Li S, Zheng J, Ren W, Zhi K: Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.Cell death & disease2022,13(2):192.(IF:9, JCR:1区，第一作者)
2. Gao L, Wang Q, Ren W, Zheng J, Li S, Dou Z, Kong X, Liang X, Zhi K: The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.Cell death & disease2020,11(6):488.(IF:9, JCR:1区，第一作者)
3. Gao L, Dou Z C, Ren W H, et al. Circcdr1as Upregulates Autophagy under Hypoxia to Promote Tumor Cell Survival Via Akt/Erk(½)/Mtor Signaling Pathways in Oral Squamous Cell Carcinomas[J]. Cell Death Dis, 2019, 10(10): 745.(IF:9, JCR:1区，第一作者)
4. Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T,Gao L: CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.Annals of the New York Academy of Sciences2021,1485(1):56-70.(IF:5.2, JCR:1区，通讯作者)
5. Wang Q, Zhi Y, Ren W, Li S, Dou Z, Xing X, Quan X, Wang Y, Jiang C, Liang X,Gao L, Zhi K:Suppression of OSCC malignancy by oral glands derived-PIP identified by iTRAQ combined with 2D LC-MS/MS.Journal of cellular physiology2019,234(9):15330-15341.（IF:5.6,JCR:1区,通讯作者）
6. Li CY,Gao L, Fan XL, Zeng RC, Chen DC, Zhi KQ: In vitro degradation and cytocompatibility of a low temperature in-situ grown self-healing Mg-Al LDH coating on MAO-coated magnesium alloy AZ31.Bioactive materials2020,5(2):364-376.（IF:18.9, JCR:1区，共同一作）
7. Wang M, Zhang L, Ren W, Li S, Zhi K, Zheng J,Gao L: Diagnostic Value of CircRNAs as Potential Biomarkers in Oral Squamous Cell Carcinoma: a Meta-Analysis.Frontiers in oncology2021,11:693284.(IF:4.7,JCR:1区，通讯作者)
8. Gao L, Zhao C, Li S, Dou Z, Wang Q, Liu J, Ren W, Zhi K: circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma.Molecular carcinogenesis2019,58(10):1783-1794.(IF:4.6, JCR:2区，第一作者)
9. Gao L, Ren W, Zhang L, Li S, Kong X, Zhang H, Dong J, Cai G, Jin C, Zheng Det al: PTENp1, a natural sponge of miR-21, mediates PTEN expression to inhibit the proliferation of oral squamous cell carcinoma.Molecular carcinogenesis2017,56(4):1322-1334.（IF:4.6, JCR:2区，第一作者）
10. Zhang Q, Jiang C, Ren W, Li S, Zheng J, Gao Y, Zhi K,Gao L: Circ-LRP6 mediates epithelial-mesenchymal transition and autophagy in oral squamous cell carcinomas. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2021,50(7):660-667.(IF:3.3, JCR:1区，通讯作者)
11. Ji XJ,Gao L, Liu JC, Wang J, Cheng Q, Li JP, Li SQ, Zhi KQ, Zeng RC, Wang ZL: Corrosion resistance and antibacterial properties of hydroxyapatite coating induced by gentamicin-loaded polymeric multilayers on magnesium alloys.Colloids and surfaces B, Biointerfaces2019,179:429-436.(IF:5.8, JCR:1区，共同一作）
12. Zhang L, Wang M, Ren W, Li S, Zhi K,Gao L, Zheng J: Prognostic significance of CircRNAs expression in oral squamous cell carcinoma. Oral diseases 2022.http://dx.doi.org/10.1111/odi.14188(IF:3.8, JCR：2区，通讯作者)
13. Sun K, Ren W, Li S, Zheng J, Huang Y, Zhi K,Gao L: MiR-34c-3p upregulates erastin-induced ferroptosis to inhibit proliferation in oral squamous cell carcinomas by targeting SLC7A11.Pathology, research and practice2022,231:153778.(IF:2.8, JCR:2区，通讯作者)
14. Liu JC,Gao L, Li SM, Zheng JJ, Li DG, Zhi KQ, Ren WH: Upregulation of XRN2 acts as an oncogene in oral squamous cell carcinoma and correlates with poor prognosis.Pathology, research and practice2021,219:153355.(IF:2.8, JCR:2区，共同一作)
15. Gao L, Wang QB, Zhi Y, Ren WH, Li SM, Zhao CY, Xing XM, Dou ZC, Liu JC, Jiang CMet al: Down-regulation of hsa_circ_0092125 is related to the occurrence and development of oral squamous cell carcinoma.International journal of oral and maxillofacial surgery2020,49(3):292-297.(IF:2.4, JCR:2区，第一作者)
16. Gao L, Liang QL, Ren WH, Li SM, Xue LF, Zhi Y, Song JZ, Wang QB, Dou ZC, Yue Jet al: Comparison of endoscope-assisted versus conventional resection of parotid tumors.The British journal of oral & maxillofacial surgery2019,57(10):1003-1008.(IF:1.8, JCR:4区，第一作者)
17. Ren W,Gao L, Qiang C, Li S, Zheng J, Wang Q, Zhi Y, Cai G, Kong X, Zhou Met al: Kindlin-2-mediated upregulation of ZEB2 facilitates migration and invasion of oral squamous cell carcinoma in a miR-200b-dependent manner.American journal of translational research2018,10(8):2529-2541.(IF:2.2, JCR:2区，共同一作)
18. Dou Z, Li S, Ren W, Wang Q, Liu J, Kong X,Gao L, Zhi K: Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma.Oral diseases2019,25(5):1302-1308.(IF:3.8, JCR：2区，通讯作者)
19. Gao L, Dong J, Zhang N, Le Z, Ren W, Li S, Li F, Song J, Wang Q, Dou Zet al: Cyclosporine A Suppresses the Malignant Progression of Oral Squamous Cell Carcinoma in vitro.Anti-cancer agents in medicinal chemistry2019,19(2):248-255.(IF:2.8 JCR：3区，第一作者)
20. Gao L, Ren W, Li S, Zheng J, Xue L, Xu Y, Wang Q, Song J, Dou Z, Zhou Met al: CBCT-based bone quality assessment in decompression of large odontogenic cystic lesions.Oral radiology2018,34(3):251-256.(IF:2.2, JCR：4区，第一作者)
21. Gao L, Ren W, Li S, Yan X, Li F, Yuan R, Shang W, Zhi K: Comparing Modified with Conventional Parotidectomy for Benign Parotid Tumors.ORL; journal for oto-rhino-laryngology and its related specialties2017,79(5):264-273.(IF:1.3, JCR：4区，第一作者)
22. Ren W,Gao L, Li S, Chen C, Li F, Wang Q, Zhi Y, Song J, Dou Z, Xue Let al: Virtual Planning and 3D printing modeling for mandibular reconstruction with fibula free flap.Medicina oral, patologia oral y cirugia bucal2018,23(3):e359-e366.(IF:2.047, JCR：3区，共同一作)
23. Ren W,Gao L, Li F, Qiang C, Li S, Zheng J, Kong X, Deng J, Cai G, Zhang Het al: Circulating high mobility group AT-hook 2 and pleomorphic adenoma gene 1 in blood of patients with oral squamous cell carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2017,46(10):998-1003.(IF:2.2, JCR：2区，共同一作)
24. Cheng Y, Li S,Gao L, Zhi K, Ren W: The Molecular Basis and Therapeutic Aspects of Cisplatin Resistance in Oral Squamous Cell Carcinoma.Frontiers in oncology2021,11:761379.(IF:4.7, JCR：1区，共同一作)
25. Xin S, Li SM,Gao L, Zheng JJ, Wu YW, Shao CL, Ren WH, Zhi K: CHNQD-00603 Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by the miR-452-3p-Mediated Autophagy Pathway.Frontiers in cell and developmental biology2021,9:779287.(IF:5.5, JCR：2区，共同一作)
26. Zhang W,Gao L, Ren W, Li S, Zheng J, Li S, Jiang C, Yang S, Zhi K: The Role of the Immune Response in the Development of Medication-Related Osteonecrosis of the Jaw.Frontiers in immunology2021,12:606043.(IF:7.3, JCR：1区，共同一作)
27. Zhi Y,Gao L, Wang B, Ren W, Liang KX, Zhi K: Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs.Frontiers in cell and developmental biology2021,9:686906.(IF:5.5, JCR：2区，共同一作)
发明专利：
1.一种临床口腔检查用口部固定装置ZL 2020 2 1340412.7实用新型专利 第一位
2.一种临床口腔检查用辅助照明装置ZL 2020 2 1339296.7实用新型专利 第二位
3.上颌窦外提升骨开窗冲击器ZL 2020 2 0072822.1实用新型专利 第二位
4.一种可调节式全口无牙颌种植引导器ZL 2020 2 0687064.4实用新型专利 第二位
5.一种上颌窦外提升手术拉钩ZL 2020 2 0688076.9实用新型专利 第三位
课题 ：
1.基于海洋来源4-苯基-2(1H)-喹啉酮类衍生物CHNQD-00603的镁合金载药系统经自噬信号通路调控骨髓间充质干细胞成骨分化修复牙槽骨缺损的机制性研究，国家自然科学基金面上项目，58万，2022.01-2025.12，项目负责人
2.低氧环境下circRNA-103698作为miR-204海绵对口腔鳞状细胞癌迁移侵袭行为的机制性研究，国家自然科学基金，18万，2016.01-2018.12，项目负责人
3. circRNA-PKD2吸附miR-494调控口腔鳞癌迁移侵袭的研究，中国博士后科学基金，5万，2018.01-2019.12，项目负责人
4. circRNA-PKD2吸附miR-494调控口腔鳞癌迁移侵袭的研究，山东省重点研发计划，15万，2019.01-2020.12，项目负责人
5. circ-PKD2作为miRNAs海绵对口腔鳞状细胞癌侵袭转移行为的机制性研究，青岛市源头创新计划，10万，2017.01-2019.12，项目负责人
6.环状RNA之circ-PKD2对口腔鳞状细胞癌迁移及侵袭特性的调控研究，青岛市博士后应用研究项目，5万，2018.01-2019.12，项目负责人
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